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Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.

Phosphatidylinositol 3-kinase (PI 3-kinase) is stimulated by insulin and a variety of growth factors, but its exact role in signal transduction remains unclear. We have used a novel, highly specific inhibitor of PT 3-kinase to dissect the role of this enzyme in insulin action. Treatment of intact 3T...

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Udgivet i:Mol Cell Biol
Principais autores: Cheatham, B, Vlahos, C J, Cheatham, L, Wang, L, Blenis, J, Kahn, C R
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358862/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8007986/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.7.4902-4911.1994
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