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Enhancement or inhibition of insulin signaling by insulin receptor substrate 1 is cell context dependent.

Insulin treatment of Chinese hamster ovary (CHO) cells expressing high levels of the insulin receptor (CHO/IR cells) activates both c-fos serum response element and activator protein 1 (AP-1) reporter genes approximately 10-fold. In contrast, parental CHO cells display only two- to threefold insulin...

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Udgivet i:Mol Cell Biol
Principais autores: Yamauchi, K, Pessin, J E
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358814/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8007950/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.7.4427-4434.1994
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