Enhancement or inhibition of insulin signaling by insulin receptor substrate 1 is cell context dependent.
Insulin treatment of Chinese hamster ovary (CHO) cells expressing high levels of the insulin receptor (CHO/IR cells) activates both c-fos serum response element and activator protein 1 (AP-1) reporter genes approximately 10-fold. In contrast, parental CHO cells display only two- to threefold insulin...
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| Publicado no: | Mol Cell Biol |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358814/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8007950/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.7.4427-4434.1994 |
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