Intra-acinar trypsinogen activation is required for early pancreatic injury but not for inflammation during acute pancreatitis

BACKGROUND & AIMS: The role of trypsinogen activation in pathogenesis of acute pancreatitis (AP) has not been clearly established. METHODS: We generated and characterized mice with disruption in the gene that encodes trypsinogen7 (T7; T−/− mice), the mouse correlate of human cationic trypsinogen...

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Bibliographic Details
Main Authors: Dawra, Rajinder, Sah, Raghuwash P., Dudeja, Vikas, Rishi, Loveena, Saluja, Ashok K.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587766/
https://ncbi.nlm.nih.gov/pubmed/21875495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.08.033
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