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Intra-acinar trypsinogen activation is required for early pancreatic injury but not for inflammation during acute pancreatitis
BACKGROUND & AIMS: The role of trypsinogen activation in pathogenesis of acute pancreatitis (AP) has not been clearly established. METHODS: We generated and characterized mice with disruption in the gene that encodes trypsinogen7 (T7; T−/− mice), the mouse correlate of human cationic trypsinogen...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3587766/ https://ncbi.nlm.nih.gov/pubmed/21875495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.08.033 |
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