A Kinome Screen Identifies Checkpoint Kinase 1 (CHK1) as a Sensitizer for RRM1-Dependent Gemcitabine Efficacy

Gemcitabine is among the most efficacious and widely used antimetabolite agents. Its molecular targets are ribonucleotide reductase M1 (RRM1) and elongating DNA. Acquired and de novo resistance as a result of RRM1 overexpression are major obstacles to therapeutic efficacy. We deployed a synthetic le...

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Hlavní autoři: Zhou, Jun, Chen, Zhengming, Malysa, Agnes, Li, Xin, Oliveira, Paula, Zhang, Yingtao, Bepler, Gerold
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587420/
https://ncbi.nlm.nih.gov/pubmed/23483975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058091
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