A Kinome Screen Identifies Checkpoint Kinase 1 (CHK1) as a Sensitizer for RRM1-Dependent Gemcitabine Efficacy

Gemcitabine is among the most efficacious and widely used antimetabolite agents. Its molecular targets are ribonucleotide reductase M1 (RRM1) and elongating DNA. Acquired and de novo resistance as a result of RRM1 overexpression are major obstacles to therapeutic efficacy. We deployed a synthetic le...

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Detalhes bibliográficos
Main Authors: Zhou, Jun, Chen, Zhengming, Malysa, Agnes, Li, Xin, Oliveira, Paula, Zhang, Yingtao, Bepler, Gerold
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587420/
https://ncbi.nlm.nih.gov/pubmed/23483975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058091
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