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pH-sensitive poly(histidine)-PEG/DSPE-PEG co-polymer micelles for cytosolic drug delivery

To introduce pH sensitivity into the DSPE-PEG-based micellar system and achieve the quick intracellular drug release in response to the acidity in endosomes, a mixed polymeric micelle was developed based on three grafted copolymers, including 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethyl...

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Main Authors: Wu, Hong, Zhu, Lin, Torchilin, Vladimir P.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587181/
https://ncbi.nlm.nih.gov/pubmed/23102622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2012.08.072
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