Distinct Roles In Vivo for the Ubiquitin–Proteasome System and the Autophagy–Lysosomal Pathway in the Degradation of α-Synuclein

Increased intracellular levels of α-synuclein are implicated in Parkinson's disease and related disorders and may be caused by alterations in the ubiquitin–proteasome system (UPS) or the autophagy–lysosomal pathway (ALP). A critical question remains how α-synuclein is degraded by neurons in viv...

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Main Authors: Ebrahimi-Fakhari, Darius, Cantuti-Castelvetri, Ippolita, Fan, Zhanyun, Rockenstein, Edward, Masliah, Eliezer, Hyman, Bradley T., McLean, Pamela J., Unni, Vivek K.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587176/
https://ncbi.nlm.nih.gov/pubmed/21994367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1560-11.2011
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