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Regulatory Light Chain Mutants Linked to Heart Disease Modify the Cardiac Myosin Lever-Arm

Myosin is the chemomechanical energy transducer in striated heart muscle. The myosin cross-bridge applies impulsive force to actin while consuming ATP chemical energy to propel myosin thick filaments relative to actin thin filaments in the fiber. Transduction begins with ATP hydrolysis in the cross-...

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Bibliografiske detaljer
Main Authors: Burghardt, Thomas P., Sikkink, Laura A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587134/
https://ncbi.nlm.nih.gov/pubmed/23343568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301500d
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