GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

Efficient engulfment of apoptotic cells is critical for maintaining tissue homoeostasis. When phagocytes recognize ‘eat me’ signals presented on the surface of apoptotic cells, this subsequently induces cytoskeletal rearrangement of phagocytes for the engulfment through Rac1 activation. However, the...

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Main Authors: Nakaya, Michio, Tajima, Mitsuru, Kosako, Hidetaka, Nakaya, Takeo, Hashimoto, Akiko, Watari, Kenji, Nishihara, Hiroaki, Ohba, Mina, Komiya, Shiori, Tani, Naoki, Nishida, Motohiro, Taniguchi, Hisaaki, Sato, Yoji, Matsumoto, Mitsuru, Tsuda, Makoto, Kuroda, Masahiko, Inoue, Kazuhide, Kurose, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado: Nature Pub. Group 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586722/
https://ncbi.nlm.nih.gov/pubmed/23443560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2540
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