GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

Efficient engulfment of apoptotic cells is critical for maintaining tissue homoeostasis. When phagocytes recognize ‘eat me’ signals presented on the surface of apoptotic cells, this subsequently induces cytoskeletal rearrangement of phagocytes for the engulfment through Rac1 activation. However, the...

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Detalhes bibliográficos
Main Authors: Nakaya, Michio, Tajima, Mitsuru, Kosako, Hidetaka, Nakaya, Takeo, Hashimoto, Akiko, Watari, Kenji, Nishihara, Hiroaki, Ohba, Mina, Komiya, Shiori, Tani, Naoki, Nishida, Motohiro, Taniguchi, Hisaaki, Sato, Yoji, Matsumoto, Mitsuru, Tsuda, Makoto, Kuroda, Masahiko, Inoue, Kazuhide, Kurose, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586722/
https://ncbi.nlm.nih.gov/pubmed/23443560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2540
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