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Organocatalytic Multicomponent Reaction for the Acquisition of a Selective Inhibitor of mPTPB, a Virulence Factor of Tuberculosis

Mycobacterium protein tyrosine phosphatase B (mPTPB) is essential for the survival and persistence of Mycobacterium in the host. Thus small molecule inhibitors of mPTPB are potential anti-TB agents. We developed an efficient organocatalytic multicomponent reaction (MCR) between pyrrole, formaldehyde...

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Autori principali: He, Rongjun, Zeng, Li-Fan, He, Yantao, Wu, Li, Gunawan, Andrea Michelle, Zhang, Zhong-Yin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586706/
https://ncbi.nlm.nih.gov/pubmed/23380872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc38961h
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