Transgenic Mice Overexpressing Neuregulin-1 Model Neurofibroma-Malignant Peripheral Nerve Sheath Tumor Progression and Implicate Specific Chromosomal Copy Number Variations in Tumorigenesis

Patients with neurofibromatosis type 1 (NF1) develop benign plexiform neurofibromas that frequently progress to become malignant peripheral nerve sheath tumors (MPNSTs). A genetically engineered mouse model that accurately models plexiform neurofibroma–MPNST progression in humans would facilitate id...

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Detalhes bibliográficos
Main Authors: Kazmi, Syed J., Byer, Stephanie J., Eckert, Jenell M., Turk, Amy N., Huijbregts, Richard P.H., Brossier, Nicole M., Grizzle, William E., Mikhail, Fady M., Roth, Kevin A., Carroll, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2013
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586689/
https://ncbi.nlm.nih.gov/pubmed/23321323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.11.017
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