Transgenic Mice Overexpressing Neuregulin-1 Model Neurofibroma-Malignant Peripheral Nerve Sheath Tumor Progression and Implicate Specific Chromosomal Copy Number Variations in Tumorigenesis

Patients with neurofibromatosis type 1 (NF1) develop benign plexiform neurofibromas that frequently progress to become malignant peripheral nerve sheath tumors (MPNSTs). A genetically engineered mouse model that accurately models plexiform neurofibroma–MPNST progression in humans would facilitate id...

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Detaylı Bibliyografya
Asıl Yazarlar: Kazmi, Syed J., Byer, Stephanie J., Eckert, Jenell M., Turk, Amy N., Huijbregts, Richard P.H., Brossier, Nicole M., Grizzle, William E., Mikhail, Fady M., Roth, Kevin A., Carroll, Steven L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Investigative Pathology 2013
Konular:
Regular Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586689/
https://ncbi.nlm.nih.gov/pubmed/23321323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.11.017
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