Inactivation of the BH3-only Protein BAD by IKK Inhibits TNFα-induced Apoptosis Independently of NF-κB activation

The IκB kinase complex (IKK) is a key regulator of immune responses, inflammation, cell survival, and tumorigenesis. The pro-survival function of IKK centers on activation of the transcription factor NF-κB, whose target gene products inhibit caspases and prevent prolonged JNK activation. Here we rep...

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Detalhes bibliográficos
Main Authors: Yan, Jie, Xiang, Jialing, Lin, Yutin, Ma, Jingui, Zhang, Jiyan, Zhang, Hao, Sun, Jisheng, Danial, Nika N., Liu, Jing, Lin, Anning
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586589/
https://ncbi.nlm.nih.gov/pubmed/23332762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.12.021
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