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The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix.

Three distinct hepatocyte nuclear factor 3 (HNF-3) proteins (HNF-3 alpha, -3 beta, and -3 gamma) are known to regulate the transcription of liver-specific genes. The HNF-3 proteins bind to DNA as a monomer through a modified helix-turn-helix, known as the winged helix motif, which is also utilized b...

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Pubblicato in:Mol Cell Biol
Autori principali: Overdier, D G, Porcella, A, Costa, R H
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 1994
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358641/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8139574/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.4.2755
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