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Critical role of charged residues in helix 7 of the ligand binding domain in Hepatocyte Nuclear Factor 4α dimerisation and transcriptional activity

Hepatocyte Nuclear Factor 4α (HNF4α, NR2A1) is central to hepatocyte and pancreatic β-cell functions. Along with retinoid X receptor α (RXRα), HNF4α belongs to the nuclear receptor subfamily 2 (NR2), characterised by a conserved arginyl residue and a glutamate residue insert in helix 7 (H7) of the l...

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Autori principali: Eeckhoute, Jérôme, Oxombre, Bénédicte, Formstecher, Pierre, Lefebvre, Philippe, Laine, Bernard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC275546/
https://ncbi.nlm.nih.gov/pubmed/14602925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg850
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