Smad4-Irf6 genetic interaction and TGFβ-mediated IRF6 signaling cascade are crucial for palatal fusion in mice

Cleft palate is one of the most common human birth defects and is associated with multiple genetic and environmental risk factors. Although mutations in the genes encoding transforming growth factor beta (TGFβ) signaling molecules and interferon regulatory factor 6 (Irf6) have been identified as gen...

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Bibliographic Details
Main Authors: Iwata, Jun-ichi, Suzuki, Akiko, Pelikan, Richard C., Ho, Thach-Vu, Sanchez-Lara, Pedro A., Urata, Mark, Dixon, Michael J., Chai, Yang
Format: Artigo
Language:Inglês
Published: Company of Biologists 2013
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585659/
https://ncbi.nlm.nih.gov/pubmed/23406900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.089615
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