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Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice
Patients with mutations in either TGF-β receptor type I (TGFBR1) or TGF-β receptor type II (TGFBR2), such as those with Loeys-Dietz syndrome, have craniofacial defects and signs of elevated TGF-β signaling. Similarly, mutations in TGF-β receptor gene family members cause craniofacial deformities, su...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3287237/ https://ncbi.nlm.nih.gov/pubmed/22326956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61498 |
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