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Enhancing Human Spermine Synthase Activity by Engineered Mutations

Spermine synthase (SMS) is an enzyme which function is to convert spermidine into spermine. It was shown that gene defects resulting in amino acid changes of the wild type SMS cause Snyder-Robinson syndrome, which is a mild-to-moderate mental disability associated with osteoporosis, facial asymmetry...

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Bibliografske podrobnosti
Main Authors: Zhang, Zhe, Zheng, Yueli, Petukh, Margo, Pegg, Anthony, Ikeguchi, Yoshihiko, Alexov, Emil
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585406/
https://ncbi.nlm.nih.gov/pubmed/23468611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002924
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