Liposomal Targeting of Prednisolone Phosphate to Synovial Lining Macrophages during Experimental Arthritis Inhibits M1 Activation but Does Not Favor M2 Differentiation

BACKGROUND: To determine the effects of liposomal targeting of prednisolone phosphate (Lip-PLP) to synovial lining macrophages on M1 and M2 polarization in vitro and during experimental arthritis. MATERIAL AND METHODS: Experimental arthritis (antigen and immune complex induced) was elicited in mice...

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Autores principales: Hofkens, Wouter, Schelbergen, Rik, Storm, Gert, van den Berg, Wim B., van Lent, Peter L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585322/
https://ncbi.nlm.nih.gov/pubmed/23468840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054016
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