Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration

Drug delivery to atherosclerotic plaques via liposomal nanoparticles may improve therapeutic agents’ risk–benefit ratios. Our paper details the first clinical studies of a liposomal nanoparticle encapsulating prednisolone (LN-PLP) in atherosclerosis. First, PLP’s liposomal encapsulation improved its...

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Published in:Nanomedicine
Main Authors: van der Valk, Fleur M., van Wijk, Diederik F., Lobatto, Mark E., Verberne, Hein J., Storm, Gert, Willems, Martine C.M., Legemate, Dink A., Nederveen, Aart J., Calcagno, Claudia, Mani, Venkatesh, Ramachandran, Sarayu, Paridaans, Maarten P.M., Otten, Maarten J., Dallinga-Thie, Geesje M., Fayad, Zahi A., Nieuwdorp, Max, Schulte, Dominik M., Metselaar, Josbert M., Mulder, Willem J.M., Stroes, Erik S.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625798/
https://ncbi.nlm.nih.gov/pubmed/25791806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2015.02.021
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