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Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis

Objective: To investigate the effect of a single intravenous treatment with glucocorticoids (GC) encapsulated in long-circulating PEG-liposomes on both joint inflammation and cartilage destruction and to investigate the phenomenon of selective homing of these liposomes in the inflamed synovium. Meth...

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Main Authors: Metselaar, J, van den Berg, W B, Holthuysen, A, Wauben, M, Storm, G, van Lent, P L E M
格式: Artigo
語言:Inglês
出版: 2004
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1754935/
https://ncbi.nlm.nih.gov/pubmed/15020326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2003.009944
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