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The N-Terminal Sequence of Prion Protein Consists an Epitope Specific to the Abnormal Isoform of Prion Protein (PrP(Sc))

The conformation of abnormal prion protein (PrP(Sc)) differs from that of cellular prion protein (PrP(C)), but the precise characteristics of PrP(Sc) remain to be elucidated. To clarify the properties of native PrP(Sc), we attempted to generate novel PrP(Sc)-specific monoclonal antibodies (mAbs) by...

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Bibliografiske detaljer
Main Authors: Masujin, Kentaro, Kaku-Ushiki, Yuko, Miwa, Ritsuko, Okada, Hiroyuki, Shimizu, Yoshihisa, Kasai, Kazuo, Matsuura, Yuichi, Yokoyama, Takashi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585212/
https://ncbi.nlm.nih.gov/pubmed/23469131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058013
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