A Natural Inactivating Mutation in the CovS Component of the CovRS Regulatory Operon in a Pattern D Streptococcal pyogenes Strain Influences Virulence-associated Genes

A skin-tropic invasive group A Streptococcus pyogenes (GAS) strain, AP53, contains a natural inactivating mutation in the covS gene (covS(M)) of the two-component responder (CovR)/sensor (CovS) gene regulatory system. The effects of this mutation on specific GAS virulence determinants have been asse...

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Autori principali: Liang, Zhong, Zhang, Yueling, Agrahari, Garima, Chandrahas, Vishwanatha, Glinton, Kristofor, Donahue, Deborah L., Balsara, Rashna D., Ploplis, Victoria A., Castellino, Francis J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585089/
https://ncbi.nlm.nih.gov/pubmed/23316057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.442657
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