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The Ikaros Transcription Factor Regulates Responsiveness to IL-12 and Expression of IL-2 Receptor Alpha in Mature, Activated CD8 T Cells

The Ikaros family of transcription factors is critical for normal T cell development while limiting malignant transformation. Mature CD8 T cells express multiple Ikaros family members, yet little is known about their function in this context. To test the functions of this gene family, we used retrov...

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Detalhes bibliográficos
Main Authors: Clambey, Eric T., Collins, Bernard, Young, Mary H., Eberlein, Jens, David, Alexandria, Kappler, John W., Marrack, Philippa
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585008/
https://ncbi.nlm.nih.gov/pubmed/23483882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057435
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