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CD8 T Cell Clonal Expansions & Aging: A Heterogeneous Phenomenon with a Common Outcome

A highly diverse CD8 T cell repertoire is thought to be critical for maintaining appropriate immune defenses against a variety of pathogens. However, in many aged individuals, the diversity of T cell receptors is significantly reduced by the presence of large, monoclonal expansions of CD8 memory T c...

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Main Authors: Clambey, Eric T., Kappler, John W., Marrack, Philippa
Formato: Artigo
Idioma:Inglês
Publicado: 2007
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905459/
https://ncbi.nlm.nih.gov/pubmed/17197145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2006.11.008
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