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Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC Genes Results in Attenuation for Growth in Human Macrophages and In Vivo Virulence in Mice and Reveals a Unique Phenotype for pdpC

Francisella tularensis is a facultative intracellular bacterial pathogen and the causative agent of tularemia. After infection of macrophages, the organism escapes from its phagosome and replicates to high density in the cytosol, but the bacterial factors required for these aspects of virulence are...

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Bibliografiske detaljer
Main Authors: Long, Matthew E., Lindemann, Stephen R., Rasmussen, Jed A., Jones, Bradley D., Allen, Lee-Ann H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584877/
https://ncbi.nlm.nih.gov/pubmed/23275090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00822-12
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