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Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC Genes Results in Attenuation for Growth in Human Macrophages and In Vivo Virulence in Mice and Reveals a Unique Phenotype for pdpC

Francisella tularensis is a facultative intracellular bacterial pathogen and the causative agent of tularemia. After infection of macrophages, the organism escapes from its phagosome and replicates to high density in the cytosol, but the bacterial factors required for these aspects of virulence are...

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Bibliografiset tiedot
Päätekijät: Long, Matthew E., Lindemann, Stephen R., Rasmussen, Jed A., Jones, Bradley D., Allen, Lee-Ann H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584877/
https://ncbi.nlm.nih.gov/pubmed/23275090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00822-12
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