Full-Length Plasmodium falciparum Circumsporozoite Protein Administered with Long-Chain Poly(I·C) or the Toll-Like Receptor 4 Agonist Glucopyranosyl Lipid Adjuvant-Stable Emulsion Elicits Potent Antibody and CD4(+) T Cell Immunity and Protection in Mice

The Plasmodium falciparum circumsporozoite (CS) protein (CSP) is a major vaccine target for preventing malaria infection. Thus, developing strong and durable antibody and T cell responses against CSP with novel immunogens and potent adjuvants may improve upon the success of current approaches. Here,...

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Detalhes bibliográficos
Main Authors: Kastenmüller, Kathrin, Espinosa, Diego A., Trager, Lauren, Stoyanov, Cristina, Salazar, Andres M., Pokalwar, Santosh, Singh, Sanjay, Dutta, Sheetij, Ockenhouse, Christian F., Zavala, Fidel, Seder, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584875/
https://ncbi.nlm.nih.gov/pubmed/23275094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01108-12
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