NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor in human gastric cancer cells harboring KRAS mutations

Aberrations of Phosphoinositide 3-kinase (PI3K)/AKT signaling are frequently observed in many types of cancer, promoting its emergence as a promising target for cancer treatment. PI3K can become activated by various pathways, one of which includes RAS. RAS can not only directly activate the PI3K/AKT...

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Main Authors: PARK, EUNJU, PARK, JINAH, HAN, SAE-WON, IM, SEOCK-AH, KIM, TAE-YOU, OH, DO-YOUN, BANG, YUNG-JUE
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584651/
https://ncbi.nlm.nih.gov/pubmed/22159814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2011.1290
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