Combination of 5-Fluorouracil and N(1),N(11)-Diethylnorspermine Markedly Activates Spermidine/Spermine N(1)-Acetyltransferase Expression, Depletes Polyamines, and Synergistically Induces Apoptosis in Colon Carcinoma Cells

The thymidylate synthase inhibitor 5-fluorouracil (5-FU) is used widely for chemotherapy of colorectal carcinoma. Recent studies showed that 5-FU affects polyamine metabolism in colon carcinoma cells. We therefore examined whether combinations of 5-FU with drugs that specifically target polyamine me...

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Main Authors: Choi, Woonyoung, Gerner, Eugene W., Ramdas, Latha, Dupart, Jheri, Carew, Jennifer, Proctor, Lynsey, Huang, Peng, Zhang, Wei, Hamilton, Stanley R.
Format: Artigo
Jezik:Inglês
Izdano: 2004
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584635/
https://ncbi.nlm.nih.gov/pubmed/15546879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M409930200
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