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Combination of 5-Fluorouracil and N(1),N(11)-Diethylnorspermine Markedly Activates Spermidine/Spermine N(1)-Acetyltransferase Expression, Depletes Polyamines, and Synergistically Induces Apoptosis in Colon Carcinoma Cells
The thymidylate synthase inhibitor 5-fluorouracil (5-FU) is used widely for chemotherapy of colorectal carcinoma. Recent studies showed that 5-FU affects polyamine metabolism in colon carcinoma cells. We therefore examined whether combinations of 5-FU with drugs that specifically target polyamine me...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3584635/ https://ncbi.nlm.nih.gov/pubmed/15546879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M409930200 |
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