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Can Telomere Shortening in Human Peripheral Blood Leukocytes Serve as a Disease Biomarker of Friedreich's Ataxia?

Enhanced oxidative stress and inflammation contribute to telomere erosion. Friedreich's ataxia is a neurodegenerative disorder caused by a reduction in frataxin expression that results in mitochondrial dysfunction and oxidative damage. Furthermore, frataxin deficiency induces a strong activatio...

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Detalhes bibliográficos
Main Authors: Castaldo, Imma, Vergara, Paola, Pinelli, Michele, Filla, Alessandro, De Michele, Giuseppe, Cocozza, Sergio, Monticelli, Antonella
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584504/
https://ncbi.nlm.nih.gov/pubmed/23146029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.5009
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