Could MDMA Promote Stemness Characteristics in Mouse Embryonic Stem Cells via mGlu5 Metabotropic Glutamate Receptors?

OBJECTIVE: Ecstasy, or 3, 4 (±) methylenedioxymethamphetamine (MDMA), is a potent neurotoxic drug. One of the mechanisms for its toxicity is the secondary release of glutamate. Mouse embryonic stem cells (mESCs) express only one glutamate receptor, the metabotropic glutamate receptor 5 (mGlu5), whic...

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Detalhes bibliográficos
Main Authors: Meamar, Rokhsareh, Karamali, Fereshte, Mousavi, Seyed Ali, Baharvand, Hossein, Nasr-Esfahani, Mohammad Hossein
Formato: Artigo
Idioma:Inglês
Publicado em: Royan Institute 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584439/
https://ncbi.nlm.nih.gov/pubmed/23508940
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