Rapamycin increases neuroblastoma xenograft and host stromal derived osteoprotegerin inhibiting osteolytic bone disease in a bone metastasis model

PURPOSE: Osteoprotegerin (OPG) is a decoy receptor for the Receptor of NF-κB (RANK) ligand that can inhibit osteoclastogenesis. Previous studies have suggested that Mammalian Target of Rapamycin (mTOR) inhibition upregulates OPG production. We tested the hypothesis that the mTOR inhibitor rapamycin...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Hartwich, Joseph E., Orr, W. Shannon, Ng, Catherine Y., Spence, Yunyu, McLaughlin, Jillian M., Furman, Wayne L., McGregor, Lisa M., Davidoff, Andrew M.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584337/
https://ncbi.nlm.nih.gov/pubmed/23331792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpedsurg.2012.10.043
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki