Neural Progenitor Cell-Mediated Delivery of Osteoprotegerin Limits Disease Progression in a Pre-Clinical Model of Neuroblastoma Bone Metastasis

PURPOSE: Osteoprotegerin (OPG) inhibits osteoclast activation and reduces osteolysis in bone tumors. We hypothesized that tumor-tropic neural progenitor cells (NPCs) engineered to express OPG would reduce neuroblastoma disease burden in the bone. METHODS: Stable expression of green fluorescent prote...

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Detalhes bibliográficos
Main Authors: Sims, Thomas L., Hamner, J. Blair, Bush, Rebecca A., Fischer, Peter E., Kim, Seung U., Aboody, Karen S., McCarville, Beth, Danks, Mary K., Davidoff, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655202/
https://ncbi.nlm.nih.gov/pubmed/19159744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpedsurg.2008.10.041
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