Inhibition of the NAD-Dependent Protein Deacetylase SIRT2 Induces Granulocytic Differentiation in Human Leukemia Cells

Sirtuins, NAD-dependent protein deacetylases, play important roles in cellular functions such as metabolism and differentiation. Whether sirtuins function in tumorigenesis is still controversial, but sirtuins are aberrantly expressed in tumors, which may keep cancerous cells undifferentiated. Theref...

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Hlavní autoři: Sunami, Yoshitaka, Araki, Marito, Hironaka, Yumi, Morishita, Soji, Kobayashi, Masaki, Liew, Ei Leen, Edahiro, Yoko, Tsutsui, Miyuki, Ohsaka, Akimichi, Komatsu, Norio
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584049/
https://ncbi.nlm.nih.gov/pubmed/23460888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057633
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