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Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members.

Recombinant expression of a chimeric EGFR/ErbB-3 receptor in NIH 3T3 fibroblasts allowed us to investigate cytoplasmic events associated with ErbB-3 signal transduction upon ligand activation. An EGFR/ErbB-3 chimera was expressed on the surface of NIH 3T3 transfectants as two classes of receptors po...

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Udgivet i:Mol Cell Biol
Principais autores: Fedi, P, Pierce, J H, di Fiore, P P, Kraus, M H
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358399/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8264617/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.1.492-500.1994
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