Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520.

We have recently reported that expression in yeast cells of P-glycoprotein (P-gp) encoded by the mouse multidrug resistance mdr3 gene (Mdr3) can complement a null ste6 mutation (M. Raymond, P. Gros, M. Whiteway, and D. Y. Thomas, Science 256:232-234, 1992). Here we show that Mdr3 behaves as a fully...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Raymond, M, Ruetz, S, Thomas, D Y, Gros, P
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358377/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7505392/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.1.277-286.1994
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