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Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520.

We have recently reported that expression in yeast cells of P-glycoprotein (P-gp) encoded by the mouse multidrug resistance mdr3 gene (Mdr3) can complement a null ste6 mutation (M. Raymond, P. Gros, M. Whiteway, and D. Y. Thomas, Science 256:232-234, 1992). Here we show that Mdr3 behaves as a fully...

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Udgivet i:Mol Cell Biol
Principais autores: Raymond, M, Ruetz, S, Thomas, D Y, Gros, P
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358377/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7505392/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.1.277-286.1994
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