The silence of MUC2 mRNA induced by promoter hypermethylation associated with HBV in Hepatocellular Carcinoma

BACKGROUND: To evaluate the promoter methylation status of MUC2 gene and mRNA expression in patients with hepatocellular carcinoma. METHODS: We analyzed MUC2 methylation by MSP, and MUC2 mRNA by real-time PCR in 74 HCC. RESULTS: MUC2 mRNA were lower in HCC tissues (Mean (-ΔCt) = −4.70) than that in...

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Библиографические подробности
Главные авторы: Ling, Yang, Zhu, Jing, Gao, Lu, Liu, Yongping, Zhu, Changtai, Li, Rong, Wei, Lixin, Zhang, Changsong
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583682/
https://ncbi.nlm.nih.gov/pubmed/23347460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-14-14
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