Novel aspects of Kindlin-3 function in humans based on a new case of Leukocyte Adhesion Deficiency III (LAD-III)

BACKGROUND: Kindlin-3 is a novel integrin activator in hematopoietic cells and its deficiency leads to immune problems and severe bleeding, known as LAD-III. Our current understanding of Kindlin-3 function primarily relies on analysis of animal models or cell lines. OBJECTIVES: To understand the fun...

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Main Authors: Meller, Julia, Malinin, Nikolay L., Panigrahi, Soumya, Kerr, Bethany A., Patil, Arohi, Ma, Yi, Venkateswaran, Lakshmi, Rogozin, Igor B., Mohandas, Narla, Ehlayel, Mohammed S., Podrez, Eugene A., Chinen, Javier, Byzova, Tatiana V.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583563/
https://ncbi.nlm.nih.gov/pubmed/22564402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2012.04768.x
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