Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation

Radiation therapy remains the standard of care for many cancers, including the malignant pediatric brain tumor medulloblastoma. Radiation leads to long-term side effects, while radio-resistance contributes to tumor recurrence. Radio-resistant medulloblastoma cells occupy the peri-vascular niche. The...

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Hauptverfasser: Fernandez-L, Africa, Squatrito, Massimo, Northcott, Paul, Awan, Aashir, Holland, Eric C., Taylor, Michael D., Nahlé, Zaher, Kenney, Anna Marie
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583298/
https://ncbi.nlm.nih.gov/pubmed/21874045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.379
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