YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

Medulloblastoma is the most common solid malignancy of childhood, with treatment side effects reducing survivors’ quality of life and lethality being associated with tumor recurrence. Activation of the Sonic hedgehog (Shh) signaling pathway is implicated in human medulloblastomas. Cerebellar granule...

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Bibliographische Detailangaben
Hauptverfasser: Fernandez-L, Africa, Northcott, Paul A., Dalton, James, Fraga, Charles, Ellison, David, Angers, Stephane, Taylor, Michael D., Kenney, Anna Marie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2009
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788333/
https://ncbi.nlm.nih.gov/pubmed/19952108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1824509
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