Network Analysis of the Focal Adhesion to Invadopodia Transition Identifies a PI3K-PKCα Invasive Signaling Axis

A central and unresolved question in cancer is how deregulated signaling leads to acquisition of an invasive cellular phenotype. Here, we modeled the invasive transition as a theoretical switch between focal adhesions and extracellular matrix (ECM)-degrading invadopodia and built molecular interacti...

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Библиографические подробности
Главные авторы: Hoshino, Daisuke, Jourquin, Jerome, Emmons, S. Weller, Miller, Tyne, Goldgof, Margalit, Costello, Kaitlin, Tyson, Darren R., Brown, Brandee, Lu, Yiling, Prasad, Nagendra K., Zhang, Bing, Mills, Gordon B., Yarbrough, Wendell G., Quaranta, Vito, Seiki, Motoharu, Weaver, Alissa M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583194/
https://ncbi.nlm.nih.gov/pubmed/22969158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002964
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