Establishment and Validation of Computational Model for MT1-MMP Dependent ECM Degradation and Intervention Strategies

MT1-MMP is a potent invasion-promoting membrane protease employed by aggressive cancer cells. MT1-MMP localizes preferentially at membrane protrusions called invadopodia where it plays a central role in degradation of the surrounding extracellular matrix (ECM). Previous reports suggested a role for...

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Main Authors: Hoshino, Daisuke, Koshikawa, Naohiko, Suzuki, Takashi, Quaranta, Vito, Weaver, Alissa M., Seiki, Motoharu, Ichikawa, Kazuhisa
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325185/
https://ncbi.nlm.nih.gov/pubmed/22511862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002479
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