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TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids
The capsaicin receptor, TRPV1, is regulated by phosphatidylinositol-4,5-bisphosphate (PIP(2)), although the precise nature of this effect (i.e., positive or negative) remains controversial. Here, we reconstitute purified TRPV1 into artificial liposomes, where it is gated robustly by capsaicin, proto...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3583019/ https://ncbi.nlm.nih.gov/pubmed/23439120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.12.016 |
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