[(3)H]4-(Dimethylamino)-N-(4-(4-(2-Methoxyphenyl)Piperazin-1-yl)-Butyl)Benzamide: A Selective Radioligand for Dopamine D(3) receptors. II. Quantitative Analysis of Dopamine D(3) and D(2) Receptor Density Ratio in the Caudate-Putamen

4-(Dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-benzamide (WC-10), a N-phenyl piperazine analog, displays high affinity and moderate selectivity for dopamine D(3) receptors versus dopamine D(2) receptors (Chu et al. [2005] Bioorg Med Chem 13:77–87). In this study, WC-10 was radiolab...

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Main Authors: XU, JINBIN, HASSANZADEH, BABAK, CHU, WENHUA, TU, ZHUDE, JONES, LYNNE A., LUEDTKE, ROBERT R., PERLMUTTER, JOEL S., MINTUN, MARK A., MACH, ROBERT H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583018/
https://ncbi.nlm.nih.gov/pubmed/20175227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/syn.20748
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