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PXR antagonists and implication in drug metabolism

Adopted orphan nuclear receptor (NR), pregnane X receptor (PXR), plays a central role in the regulation of xeno- and endobiotic metabolism. Since the discovery of the functional role of PXR in 1998, there is evolving evidence for the role of PXR agonists in abrogating metabolic pathophysiology (e.g....

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Bibliografische gegevens
Hoofdauteurs: Mani, Sridhar, Dou, Wei, Redinbo, Matthew R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583015/
https://ncbi.nlm.nih.gov/pubmed/23330542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/03602532.2012.746363
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