Characterization of cells resistant to the potent histone deacetylase inhibitor spiruchostatin B (SP-B) and effect of overexpressed p21(waf1/cip1) on the SP-B resistance or susceptibility of human leukemia cells

We previously showed that the B cell leukemia cell line NALM-6 had the highest susceptibility among a number of leukemia cell lines to spiruchostatin B (SP-B), a potent histone deacetylase (HDAC) inhibitor. We also showed that SP-B-induced cytotoxicity depended on induction of apoptosis that was med...

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Main Authors: KANNO, SYU-ICHI, MAEDA, NAOYUKI, TOMIZAWA, AYAKO, YOMOGIDA, SHIN, KATOH, TADASHI, ISHIKAWA, MASAAKI
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582725/
https://ncbi.nlm.nih.gov/pubmed/22684370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2012.1507
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